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Rhamnogalacturonan II is a Toll-like receptor 4 agonist that inhibits tumor growth by activating dendritic cell-mediated CD8+ T cells
- Park, Sung Nam;
- Noh, Kyung Tae;
- Jeong, Young-Il;
- Jung, In Duk;
- Kang, Hyun Kyu;
- 외 8명
WEB OF SCIENCE
0초록
We evaluated the effectiveness of rhamnogalacturonan II (RG-II)-stimulated bone marrow-derived dendritic cells (BMDCs) vaccination on the induction of antitumor immunity in a mouse lymphoma model using EG7-lymphoma cells expressing ovalbumin (OVA). BMDCs treated with RG-II had an activated phenotype. RG-II induced interleukin (IL)-12, IL-1 beta, tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) production during dendritic cell (DC) maturation. BMDCs stimulated with RG-II facilitate the proliferation of CD8(+) T cells. Using BMDCs from the mice deficient in Toll-like receptors (TLRs), we revealed that RG-II activity is dependent on TLR4. RG-II showed a preventive effect of immunization with OVA-pulsed BMDCs against EG7 lymphoma. These results suggested that RG-II expedites the DC-based immune response through the TLR4 signaling pathway. Experimental & Molecular Medicine (2013) 45, e8; doi:10.1038/emm.2013.14; published online 8 February 2013
키워드
- 제목
- Rhamnogalacturonan II is a Toll-like receptor 4 agonist that inhibits tumor growth by activating dendritic cell-mediated CD8+ T cells
- 저자
- Park, Sung Nam; Noh, Kyung Tae; Jeong, Young-Il; Jung, In Duk; Kang, Hyun Kyu; Cha, Gil Sun; Lee, Su Jung; Seo, Jong Keun; Kang, Dae Hwan; Hwang, Tae-Ho; Lee, Eun Kyung; Kwon, Byungsuk; Park, Yeong-Min
- 발행일
- 2013-02
- 유형
- Article
- 권
- 45
- 언어
- ENG
- 출판사
- NATURE PUBLISHING GROUP
- 발행국가
- 미국
- ISSN
- E 2092-6413
P 1226-3613