Temporal Changes in Resting Heart Rate and Risk of Diabetes Mellitus

초록

Background: To investigate the association between the time-varying resting heart rate (RHR) and change in RHR (triangle RHR) over time and the risk of diabetes mellitus (DM) by sex. Methods: We assessed 8,313 participants without DM or atrial fibrillation/flutter from the Korean Genome and Epidemiology Study, a community-based prospective cohort study that was initiated in 2001 to 2002. The participants were followed up until December 31, 2018. Updating RHR with biennial in-study re-examinations, the time-varying triangle RHR was calculated by assessing the triangle RHR at the next follow-up visit. Results: Over a median follow-up of 12.3 years, 1,345 participants (16.2%) had DM. As compared with RHR of 60 to 69 bpm, for RHR of >= 80 bpm, the incidence of DM was significantly increased for both male and female. A drop of >= 5 bpm in triangle RHR when compared with the stable triangle RHR group (-5< triangle RHR <5 bpm) was associated significantly with lower risk of DM in both male and female. However, an increase of >= 5 bpm in triangle RHR was significantly associated with higher risk of DM only in female, not in male (hazard ratio for male, 1.057 [95% confidence interval, 0.869 to 1.285]; and for female, 1.218 [95% confidence interval, 1.008 to Conclusion: In this community-based longitudinal cohort study, a reduction in triangle RHR was associated with a decreased risk of DM, while an increase in triangle RHR was associated with an increased risk of DM only in female.

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